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Thomas Frieden, MD, MPH, director of the CDC, and Susan Desmond-Hellmann, MD, chief executive of the Bill and Melinda Gates Foundation discuss how governments and business organizations should prepare for pandemics, especially a potential influenza pandemic.

Recent outbreaks of highly pathogenic H5N8 avian influenza in Northern Europe, Russia, and the Middle East are worrying neighboring countries and have led to the culling of tens of thousands of chicken, turkeys, and ducks.