Kenneth Bender, PharmD, MA

An investigational microbiome-based therapeutic for C difficile was found to exert continued efficacy 3 months after administration.

Antiviral therapy that suppresses HIV-1 viremia does not block release of cell-associated RNA after infection or the inflammatory response it provokes.

Patients testing positive for SARS-CoV-2 after recovery and negative tests are re-examined to determine if they are reinfected and/or infectious.

The final report of remdesivir trial supports its approved treatment for COVID-19 after preliminary findings enabled emergency use authorization.

An investigational vaccine for C difficile demonstrates multiyear efficacy in trials reported at 2020 IDWeek Conference.

Phase 2 trial demonstrates novel investigational antifungal Fosmanogepix is tolerated and efficacious in patients with renal Insufficiency.

Virologists have identified a gene encoded by SARS-CoV-2 that enables it, but not SARS-CoV or Influenza A viruses, to inhibit interferon-based immune response

Invasive C glabrata found to be most prevalent strain of Candida in stool of patients with C difficile infection, and likely resistant to caspofungin.

An antiprotozoal used in veterinary medicine demonstrates potential for repurposing to replace metronidazole to treat Clostridioides difficile.

Influenza vaccination during COVID-19 could keep health resources from being overwhelmed and mitigate cardiovascular risks.

National Academies committee releases discussion draft on equitable allocation of vaccine against novel coronavirus for public comment.

Review and meta-analysis identifies clinical manifestations, risk factors, and maternal and perinatal outcomes associated with COVID-19 in pregnancy.

Outbreaks in countries with high vaccine uptake prompted reassessment of the immunogenicity and persistence of trivalent measles, mumps and rubella vaccine

The CMS Sepsis Bundle Core Performance Measure of sepsis treatment could contribute to the overuse of broad-spectrum antibiotics

The 2-step algorithm for diagnosing Clostridioides difficile infection is difficult to interpret in patients who have cancer or are immunocompromised.

Mathematical modeling for tracing COVID-19 contacts can account for likely scenarios of inconsistent physical distancing and quarantine adherence

The short-lived designation of remdesivir as an Orphan Drug to treat COVID-19 exposed loophole in the Orphan Drug Act.

A systematic review and meta-analysis was undertaken to ascertain optimal route and duration of antibiotic treatment of acute cellulitis

Postmarketing vaccine experience with vaccines suggests the candidates approved by the FDA for COVID-19 will be safe and effective

A recent increase in stress cardiomyopathy (Takotsubo Syndrome) could reflect the severe psychosocial pressures of the COVID-19 pandemic.

Although plasma levels of lopinavir increase as its metabolism is inhibited by inflammation in COVID-19, levels in the lungs remain subtherapeutic.

Contracting influenza increased the risk for invasive pneumococcal disease in a study conducted across 3 countries.

Over 200 scientists issued alert to medical community that COVID-19 is transmissible over longer distances via smaller aerosolized droplets.

Hollow-fiber infection model (HFIM) facilitates comparison of intermittent vs continuous infusion of ß-lactam antibiotic for K. pneumoniae

A high proportion of N95 masks failed to fit properly with the extended use and reuse recommended by the CDC for conserving PPE during the shortage.

Regional disparity in prior authorization requirement for insurance coverage of Pre-exposure prophylaxis (PrEP) for HIV could be discriminatory.

Less ACE2 in nasal epithelium in children could present barrier to SARS-CoV-2 and explain the lower observed rate of pediatric infections.

Adding thromboelastogram to D-dimer measure could enable early ID of patients who require aggressive anticoagulation for severe COVID-19.

Two patient case series suggest pronation could improve oxygenation with non-invasive ventilation in some patients with coronavirus.

A risk score that predicts critical illness in patients hospitalized with COVID-19 could help inform allocation of clinical resources.