Kenneth Bender, PharmD, MA

Trial of standard vs short course antimicrobial treatment of uncomplicated UTI in children favors standard, but with caveat for early responders.

Penicillin allergy is not uncommon, but its occurrence is exaggerated by erroneous allergy labeling that unnecessarily precludes treatment options.

The investigational antibiotic, clovibactin, isolated from soil bacteria demonstrates unique mechanism against conserved site on drug-resistant bacteria.

Previously estimated 0.32% HBV prevalence in the US is closer to 0.55%, according to new modeling study that accounts for immigrant population.

Investigators revisit an 80-year-old antimicrobial to reduce its toxicity while preserving its activity against drug resistant gram-negative bacteria.

Epidemiologists report cluster of pediatric intracranial abscess in Clark County, Nevada with Streptococcus intermedius the most common isolate.

The WHO issued its first ever list of priority antibiotics for pediatrics to encourage research and development targeting needs of that population.

The combination appears more likely than either agent alone to reduce risk of early COVID-19 symptoms worsening and requiring hospitalization.

First global meta-analysis of direct surveys of HIV, HCV incidence in people who inject drugs (PWID) finds youth and women most affected.

A novel "antibody-mimetic" molecule administered intranasally in animal model prevented coronavirus infection from older, current and emerging variants.

When given within 5 days of COVID-19 symptoms, Paxlovid appeared to reduce risk for developing Post-COVID-19 Conditions (PCC).

“Real-world” assessment finds nirmatrelvir-ritonavir reduces risk of severe COVID-19 from BA4 and BA5 omicron subvariants.

A booster dose of mRNA COVID-19 vaccination during pregnancy increases protection of infants from infection and related hospitalization.

Bacterial co-infections with COVID-19 are uncommon, but frequent use of antibiotics has fostered treatment resistance in co-occurring and secondary infections.

Antibiotics are apparently not the only widely used pharmaceuticals that can induce emergence of treatment resistant bacteria.

The mRNA vaccines reduced risk of COVID-19 and related complications in children, with less risk of myocarditis than is associated with the infection.

An analysis of the actions taken to combat antimicrobial resistance in 114 countries finds national action plans easier to develop than to implement.

Preclinical testing suggests that a newly developed SARS-CoV-2 vaccine could protect against current and future variants.

Alternative strategies to increase immunogenicity of COVID-19 vaccines in immunosuppressed kidney transplant recipients are evaluated in clinical trial.

Earlier and higher rates of RSV and other respiratory illnesses following reduced COVID precautions challenge capacity of pediatric units.

The World Health Organization (WHO) describes measures necessary to confront invasive fungal infections from the pathogens posing highest threat and greatest disease burden.

The World Health Organization's fungal priority pathogens list is intended to prompt research, development and policy against the increasing health threat.

Polio outbreak has CDC Advisory Committee on Immunization Practices considering a novel oral vaccine 20 years after shelving its predecessor.

CRISPR edit of proviral DNA tested as potential cure for HIV in first participant of phase 1/2 clinical trial.

Novel β-lactamase inhibitor enmetazobactam with cefepime exceeded noninferiority to piperacillin/tazobactam in complicated UTI, pyelonephritis.

Oral antibiotics after partial completion of intravenous regimen for S aureus bacteremia improves outcomes of persons who inject drugs (PWID), which is a population that often has limited access to treatment.

Largest extended study of outcomes after rare myocarditis from mRNA COVID-19 vaccines finds most recover and regain quality of life.

Occult HBV infection is likely to go undetected in under-resourced regions of high HBV endemicity and confound WHO goal to eradicate the viral hepatitis by 2030.

Progress in rapid diagnostic and point-of-care testing propelled by the pandemic can improve timeliness and precision of anti-infective treatment.

The same 5-year survival rates with kidney transplants from HCV positive and negative donors supports revising HCV "penalty" in ranking donors.