Healthcare Associated Infections (HAI)

A large majority of sepsis patients are pathogen-negative, yet empiric prescribing of antibiotics varies significantly from patient to patient.

Eravacycline may be an option for patients with a history of C diff or those with a history of infections who are at risk for developing the infection.

While infectious disease consultations reduced the amount of antibiotics used for patients, it only affected C diff rates at 1 of 3 hospitals in the study.

Keith S. Kaye, MD, MPH, discusses the current treatment landscape for pneumonia in the ICU setting, and previews the topline results of the phase 3 RESTORE-IMI 2 trial.

When guidelines are quickly implemented for C diff treatment recommendations, the changes are reflected quickly.

The high recurrence rates of Clostridioides difficile infection highlight the need for novel agents with unique mechanisms of action for treating the infection.

RBX2660, a microbiota-based drug, was safe and efficacious for preventing recurrent C diff infection with clinical durability to 24-months after treatment, independent of age or sex.

Investigators observed no moderate, severe, cumulative, or dose-limiting adverse events leading to discontinuation, and ACX-362E was generally well-tolerated at all dose levels.

When it came to infection prevention measures, 5 of the 9 Orange County facilities with C auris displayed hand hygiene adherence < 50%, 3 had limited access to alcohol-based hand rubs, and < 60% of assessed high-touch surfaces were clean.

Investigators assessed 90-day all-cause mortality between patients with Candida bloodstream infections who did and did not receive an infectious disease consultation.

Use of high-risk antibiotics is linked to C diff infections, but the class of antibiotics with the strongest link has changed over time underscoring the need for ongoing assessment.

Through June 2019, there were 725 confirmed cases of C auris in the New York City, New Jersey and Chicago regions, with 30 additional probable cases documented.

Can UV disinfecting lights tackle health care-associated infections?

A new study delves into the debate of N95 respirators versus surgical masks for seasonal influenza and other respiratory illnesses.

Study investigators assessed the nationwide incidence of sepsis within 42 days of delivery discharge.

A novel combination of ceftriaxone, sulbactam and disodium EDTA (CSE) was found noninferior to meropenem to treat cUTIs caused by gram-negative pathogens.

A new study using shotgun metagenomic sequencing found that FMT yielded a sustained decrease in antimicrobial resistance genes and potential pathogens in children with recurrent C diff.