Healthcare Associated Infections (HAI)

Keith S. Kaye, MD, MPH, discusses the current treatment landscape for pneumonia in the ICU setting, and previews the topline results of the phase 3 RESTORE-IMI 2 trial.

When guidelines are quickly implemented for C diff treatment recommendations, the changes are reflected quickly.

The high recurrence rates of Clostridioides difficile infection highlight the need for novel agents with unique mechanisms of action for treating the infection.

RBX2660, a microbiota-based drug, was safe and efficacious for preventing recurrent C diff infection with clinical durability to 24-months after treatment, independent of age or sex.

Investigators observed no moderate, severe, cumulative, or dose-limiting adverse events leading to discontinuation, and ACX-362E was generally well-tolerated at all dose levels.

When it came to infection prevention measures, 5 of the 9 Orange County facilities with C auris displayed hand hygiene adherence < 50%, 3 had limited access to alcohol-based hand rubs, and < 60% of assessed high-touch surfaces were clean.

Investigators assessed 90-day all-cause mortality between patients with Candida bloodstream infections who did and did not receive an infectious disease consultation.

Use of high-risk antibiotics is linked to C diff infections, but the class of antibiotics with the strongest link has changed over time underscoring the need for ongoing assessment.

Through June 2019, there were 725 confirmed cases of C auris in the New York City, New Jersey and Chicago regions, with 30 additional probable cases documented.

Can UV disinfecting lights tackle health care-associated infections?

A new study delves into the debate of N95 respirators versus surgical masks for seasonal influenza and other respiratory illnesses.

Study investigators assessed the nationwide incidence of sepsis within 42 days of delivery discharge.

A novel combination of ceftriaxone, sulbactam and disodium EDTA (CSE) was found noninferior to meropenem to treat cUTIs caused by gram-negative pathogens.

A new study using shotgun metagenomic sequencing found that FMT yielded a sustained decrease in antimicrobial resistance genes and potential pathogens in children with recurrent C diff.

A new study sheds light on the relationship between fungi and C diff infections.

Prescriptions are often given for antimicrobial treatment for asymptomatic bacteriuria despite national guidelines against it, which could lead to longer hospital stays, a new study found.

As the summer comes to a close, our editorial team is looking back at the top FDA approvals of 2019 to date and looking ahead at what is left on the docket this year.

The CDC hopes the case of a patient who was hospitalized in Maryland following a hospitalization in Kenya will help raise awareness of the importance of C auris screening.

Patients and health care professionals alike cite significant issues with education and emotion surrounding MDROs.

A UK study details a new way to prevent Legionnaires' disease and save energy.

Not all disinfectants are created equal and here's why we need to remember that.

Although conducting whole genomic sequencing creates an upfront cost in screening patients for MRSA, a new study finds that it’s a cost-effective way to prevent new infections and related deaths.

A 10-minute cycle of PX-UV light on glass slides inoculated with C auris reduced the number of colony forming units per milliliter by 99.6%.

A new study evaluates timelines for C diff treatment, diagnosis, and isolation.

Recent patient death calls into question viability of effective treatment for recurrent C diff.

Cases of C auris have been reported in 12 states. Investigators believe they’ve found a new way to attack the fungus using combinations of antifungal and antibacterial medications.

A new study looks at ESBL transmission and close proximity interactions.

External female catheter could be 1 strategy to reduce the prevalence of CAUTIs.

A new study finds that age, sex, and site of infection can increase the risk of long-term mortality in the first 5 years following sepsis survival.

How can we possibly clean our hands with highly contaminated sinks?