Keith S. Kaye, MD, MPH: RESTORE-IMI 2 and Treating Critically Ill Patients With Respiratory Infections
Keith S. Kaye, MD, MPH, discusses the current treatment landscape for pneumonia in the ICU setting, and previews the topline results of the phase 3 RESTORE-IMI 2 trial.
Guidelines Impact Use of Fidaxomicin in C diff Treatment
When guidelines are quickly implemented for C diff treatment recommendations, the changes are reflected quickly.
Investigational Treatments for Clostridioides difficile Infection
The high recurrence rates of Clostridioides difficile infection highlight the need for novel agents with unique mechanisms of action for treating the infection.
Phase 2 Results: Microbiota-Based RBX2660 Safe, Efficacious for Preventing C diff Recurrence
RBX2660, a microbiota-based drug, was safe and efficacious for preventing recurrent C diff infection with clinical durability to 24-months after treatment, independent of age or sex.
ACX-362E a Promising Potential Treatment for C difficile, First-in-Human Phase 1 Trial Demonstrates
Investigators observed no moderate, severe, cumulative, or dose-limiting adverse events leading to discontinuation, and ACX-362E was generally well-tolerated at all dose levels.
Early Detection and Quick Infection Prevention Support Key to Tackling Candida Auris
When it came to infection prevention measures, 5 of the 9 Orange County facilities with C auris displayed hand hygiene adherence < 50%, 3 had limited access to alcohol-based hand rubs, and < 60% of assessed high-touch surfaces were clean.
Can ID Consultations Decrease Candida Bloodstream Infection Mortality?
Investigators assessed 90-day all-cause mortality between patients with Candida bloodstream infections who did and did not receive an infectious disease consultation.
High-Risk Antibiotic Use Linked to Hospital-Associated C Diff Infections
Use of high-risk antibiotics is linked to C diff infections, but the class of antibiotics with the strongest link has changed over time underscoring the need for ongoing assessment.
The State of Candida Auris
Through June 2019, there were 725 confirmed cases of C auris in the New York City, New Jersey and Chicago regions, with 30 additional probable cases documented.
UV Disinfection Tackles MRSA—What About C Diff?
Can UV disinfecting lights tackle health care-associated infections?
Should Clinicians Use N95 Respirators to Prevent Respiratory Illness?
A new study delves into the debate of N95 respirators versus surgical masks for seasonal influenza and other respiratory illnesses.
Sepsis Responsible for Nearly a Quarter of Maternal Deaths
Study investigators assessed the nationwide incidence of sepsis within 42 days of delivery discharge.
Novel Drug Combination Noninferior for Treatment of cUTI
A novel combination of ceftriaxone, sulbactam and disodium EDTA (CSE) was found noninferior to meropenem to treat cUTIs caused by gram-negative pathogens.
FMT Decreases Antimicrobial Resistance in Study of Children with C diff
A new study using shotgun metagenomic sequencing found that FMT yielded a sustained decrease in antimicrobial resistance genes and potential pathogens in children with recurrent C diff.
C Diff and Fungi: An Unexpected Partnership
A new study sheds light on the relationship between fungi and C diff infections.
Inappropriate Treatment for Asymptomatic Bacteriuria Is Common, Risky
Prescriptions are often given for antimicrobial treatment for asymptomatic bacteriuria despite national guidelines against it, which could lead to longer hospital stays, a new study found.
FDA Activity Tracker: Top Approvals of 2019 to Date
As the summer comes to a close, our editorial team is looking back at the top FDA approvals of 2019 to date and looking ahead at what is left on the docket this year.
CDC Warns of Link Between Overseas Hospitalization, CPOs, and C auris
The CDC hopes the case of a patient who was hospitalized in Maryland following a hospitalization in Kenya will help raise awareness of the importance of C auris screening.
Perception Problems for Multidrug-Resistant Organisms
Patients and health care professionals alike cite significant issues with education and emotion surrounding MDROs.
Combatting Legionella and Carbon Footprints
A UK study details a new way to prevent Legionnaires' disease and save energy.
Breaking Down Resistant Rumors and C diff Disinfectants
Not all disinfectants are created equal and here's why we need to remember that.
Proactive WGS Offers a Cost-Effective Tool for MRSA Infection Control
Although conducting whole genomic sequencing creates an upfront cost in screening patients for MRSA, a new study finds that it’s a cost-effective way to prevent new infections and related deaths.
Pulsed-Xenon Ultraviolet Light System Demonstrates Powerful Activity Against Candida auris
A 10-minute cycle of PX-UV light on glass slides inoculated with C auris reduced the number of colony forming units per milliliter by 99.6%.
A Timestamp for C diff
A new study evaluates timelines for C diff treatment, diagnosis, and isolation.
Does FMT Have a Future?: Public Health Watch
Recent patient death calls into question viability of effective treatment for recurrent C diff.
3 Drug Combinations Appear Effective Against C auris
Cases of C auris have been reported in 12 states. Investigators believe they’ve found a new way to attack the fungus using combinations of antifungal and antibacterial medications.
Small Interactions and Big Consequences: Transmission of ESBLs
A new study looks at ESBL transmission and close proximity interactions.
New Tech Helps Cut Down on Catheter-Associated UTI Rates
External female catheter could be 1 strategy to reduce the prevalence of CAUTIs.
Study Identifies Risk Factors of Long-Term Mortality in Sepsis Survivors
A new study finds that age, sex, and site of infection can increase the risk of long-term mortality in the first 5 years following sepsis survival.
Tackling Dirty Sinks
How can we possibly clean our hands with highly contaminated sinks?
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