Real World Bezlotoxumab Use for Recurrent C diff
After the MODIFY trial, investigators wanted to explore how bezlotoxumab treated patients in the real world.
Electronic Alerts Aid in C diff Diagnostic Stewardship
An electronic alert that aids in diagnostic stewardship may be helpful in reducing inappropriate testing for C diff, according to a new study.
Can Enteral Vancomycin C Diff Prophylaxis Improve Outcomes in HSCT Recipients?
Using enteral vancomycin for C diff prophylaxis may be the key to reducing morbidity and improving outcomes in pediatric and young adult recipients of HSCT.
Nationwide Study: Sepsis Present in 1 in 3 Patients With OUD Who Died in the Hospital
Patients who had OUD and sepsis were found to be younger and healthier than patients without OUD.
Analysis Bolsters VA's Leadership Role in HAI Prevention: Public Health Watch
System hospitals are proactive in reducing incidence of C diff infections and CLABSIs, according to study in JAMA Network Open.
Understanding Clindamycin-Resistant C Diff Breakout
The new C diff strain may turn out to be particularly severe and requires sufficient monitoring.
Novel Coronavirus: Health Care and Infection Prevention Implications
In a scenario where health care preparedness is key, what are the best strategies for US hospitals to pursue?
Bezlotoxumab Treatment Reduced C diff Recurrence in Cancer Patients, Study Reports
Treatment with bezlotoxumab resulted in a statistically significant reduction of recurrent C diff in cancer patients, according to a new study.
Asymptomatic C diff Carriers Prevalent Among Admitted Hospital Patients
Some asymptomatic carriers of C diff went on to have clinical infection themselves within a 6-month period.
Earlier Initiation of Daptomycin-Ceftaroline for MRSA Bacteremia May Improve Outcomes
Earlier initiation of DAP-CPT combination therapy may be beneficial, despite a tendency to use the therapy after initial treatment failure.
Why Have Efforts to Vaccinate Against S aureus Failed?
A new study published in the Journal of Clinical Investigation may offer some insight on why past efforts to develop a vaccine for S aureus have failed.
Health Care Workers Often Work Despite Illness
Even as hospitals try to stop health care-associated illnesses, they can often have difficulty identifying which employees are too sick to work. New research suggests a high number of health care employees work while experiencing symptoms of illness.
Developing a Risk Prediction Model for Health Care-Associated C Diff Infection
A team of investigators set out to identify whether a risk prediction model that was developed at Novant Health could accurately identify individuals at a high-risk for health care-associated C diff infection.
Fidaxomicin Well-Tolerated in Pediatric C diff Cases
Prior to this study’s publication, the literature about pediatric C diff infection was limited.
Get Off the SOFA! Introducing the Quick Pitt Bacteremia Score
The quick Pitt Bacteremia Score offers accuracy comparable to the original version's across multiple infections, and maintains ease of use.
Household Environments Are a Key Reservoir for MRSA Transmission
Common interventions such as frequent hand washing can help stop the spread of methicillin-resistant Staphylococcus aureus, according to a new study that identified household environments as a reservoir for the bacteria.
Differences in C difficile Diagnostics Blunt the Benefits of Bezlotoxumab
Bezlotoxumab, a human monoclonal anti­body directed against Clostridioides diffi­cile toxin B, is currently indicated for the prevention of recurrent C diffi­cile infection
Entering the Ring: Oral Vancomycin Versus Metronidazole for C difficile Infection and the Risk of Vancomycin-Resistant Enterococcus
In 2017, a guideline update stripped metronidazole of its first-line therapy designation and crowned oral vancomycin as initial therapy for all C difficile infection cases.
Can the CDC Achieve Its C Diff Goal?: Public Health Watch
The CDC’s plan calls for 30% reduction in C diff infections, but work remains to be done.
Most Physicians Don't Follow WHO Guidelines in Neonatal, Pediatric Sepsis
A new study concluded physicians frequently deviate from WHO guidelines when treating children and newborns with sepsis. It’s unclear what impact such decisions have on patient outcomes.
Digital Alert System Cuts Odds of Sepsis-Related Mortality
The sepsis alert system works by monitoring changes in patients’ temperatures, heart rates, and glucose levels, and notifying clinicians of abnormalities through electronic health records.
Rapid Blood Assay Predicts Mortality Risk Levels of Sepsis
A new rapid blood assay could help physicians to get ahead of sepsis by predicting which patients are at low, medium and high risk for the infection.
At Risk for Acinetobacter Baumannii: Factors That Increase Colonization in Patients
From an infection prevention perspective, the nature of Acinetobacter baumannii makes it an organism on the radar for prevention efforts against health care-associated infections.
CDC Report Finds Declines in Key HAIs, but No Significant Change in Others: Public Health Watch
Agency’s annual report on healthcare-associated bugs highlights reduced incidence of CLABSI, CAUTI, and C diff.
Improvements in Understanding C diff for Health Care Facility-Associated Cases
Rates of health care facility-acquired C diff seemed to show improvement, but understanding community-acquired cases better in the future can help aid prevention efforts.
Cefiderocol vs High-Dose Meropenem for the Treatment of Patients With Nosocomial Pneumonia
Ryan K. Shields, PharmD, MS, reacts to research presented at IDWeek 2019 on cefiderocol versus high-dose meropenem for patients with nosocomial pneumonia.
Contact Precautions in Long-Term VA Facilities Don't Cut MRSA Infections, Study Shows
Although use of gowns and gloves in targeted settings may still be helpful in preventing health care-associated infections, contact precaution policies in VA long-term care facilities had no impact on MRSA acquisition.
Pathogen-Negative Sepsis Is a Strong Candidate for Stewardship
A large majority of sepsis patients are pathogen-negative, yet empiric prescribing of antibiotics varies significantly from patient to patient.
Eravacycline: The Next Frontier in C diff Treatment?
Eravacycline may be an option for patients with a history of C diff or those with a history of infections who are at risk for developing the infection.
The Impact of Infectious Disease Consults on C diff and Antibiotic Stewardship
While infectious disease consultations reduced the amount of antibiotics used for patients, it only affected C diff rates at 1 of 3 hospitals in the study.
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