Zoonotic & Vector-Borne Diseases

Takeda’s investigational dengue vaccine TAK-003 is currently under evaluation for preventing any dengue virus serotype in individuals 4-60 years old.

Dengue is the most prevalent and important mosquito-borne virus in the world. Atea Pharmaceuticals presented positive data for their direct-acting dengue antiviral, AT-752.

It’s not enough to have accurate infectious disease diagnostics, they must be accessible to the patients most affected.

Similar to HIV, the colonial and postcolonial history is fundamental to the biology of this monkeypox outbreak.

The AIDS Clinical Trials Group (ACTG) is launching a phase 3 trial to evaluate the safety and efficacy of tecovirimat to treat monkeypox in vulnerable populations.

Investigators surmise a natural bat exposure within certain areas of the world may correspond with lower COVID-19 incidence rates.

2 Washington, DC monkeypox patients presented with lesions and proctitis, and were treated with oral tecovirimat.

Ongoing wastewater surveillance in San Diego seeks to track and predict monkeypox infection surges.

Next generation antimalarial monoclonal antibody is three times more potent than predecessor in preventing parasitemia, stopping parasite replicating.

Langya virus, a new type of henipavirus, was identified in at least 35 people in eastern China. The virus is suspected to have infected shrews before jumping to humans.

The agency decided to allow for intradermal injection thus increasing the number of available doses substantially.

The federal agency and international organization offer some insights on patient epidemiology, and the high-risk groups that public health officials and clinicians should consider for vaccines and education efforts.

Declaration allows mobilization of funding, resources to address the virus.

Public health officials made the decision after seeing increasing incidence rates.

Last weekend, the World Health Organization declared the monkeypox viral outbreaks a Public Health Emergency of the International Concern (PHEIC).

With the warmer months in full swing, here are clinical considerations and strategies for tick-borne infections.

As monkeypox cases increase, investigators are turning to smallpox antivirals.

2 patients died of Marburg virus in the southern Ashanti region of Ghana. Nearly 100 close contacts are now under observation for the infectious disease, which is a cousin of the Ebola virus.

Investigators found potentially infectious monkeypox virus DNA in saliva and semen.

Research shows specific climate elements affect mosquito proliferation and can play a role in predictors of vector activity and insect control interventions.

This first study of the UK’s ongoing monkeypox outbreak reported the clinical and demographic features of 54 confirmed cases.

The World Health Organization did not declare monkeypox a global health emergency, instead calling it an “evolving health threat” that requires continued monitoring.

Using confirmed monkeypox cases in the Netherlands, investigators estimated the average time from infection to symptom onset was 8.5 days.

At separate press conferences, the CDC and WHO indicate that containing monkeypox will depend on testing, tracing, and currently available vaccines.

The CDC recently compiled surveillance data showing the span and prevalence of 7 major pathogens commonly carried by blacklegged ticks.

Tecovirimat (Tpoxx) is an antiviral agent that is already indicated for another orthopoxvirus, smallpox. And studies are ongoing to see if it has potential efficacy in treating monkeypox.

There are now over 25 monkeypox infections confirmed in 12 US states and DC. There are an estimated 900 cases worldwide.

Community transmission of monkeypox outside traditional endemic regions of the virus prompts calls for increased vigilance.