When using ceftolozane/ tazobactam to treat patients with P aeruginosa respiratory tract infections, the use of extended or continuous antibiotic infusion and/or combination therapy with other active antibiotic agents should be considered, particularly if targeting higher MIC values.
Readmission rates for patients receiving OPAT are reported to be as high as 20%, mostly due to catheter-related problems, adverse drug reactions, or worsening of the primary infection.
This article evaluates the point in microbiological workup at which results of respiratory secretion and blood cultures could be interpreted as excluding MRSA and, thus, no longer warrant the empirical vancomycin therapy.
A recent study reported the benefit of vaginal microbiome transplantation for the treatment of recurrent bacterial vaginosis.
Novel modes of delivery are imperative to improve HIV suppression and prevent transmission.
Infectious diseases clinicians turn to Twitter as a tool for education and collaboration.
In 2017, a guideline update stripped metronidazole of its first-line therapy designation and crowned oral vancomycin as initial therapy for all C difficile infection cases.
This article highlights some key updates to the antimicrobial therapy recommendations in the updated community-acquired pneumonia guidelines.
By stopping unnecessary antibiotics before they start, clinicians can avoid unnecessary harm to the patient and the population.
Novel β-lactam/β-lactamase inhibitor combinations and cefiderocol may play a part in the treatment of infections caused by Stenotrophomonas maltophilia, Achromobacter xylosoxidans, and Burkholderia cepacia complex.
The high recurrence rates of Clostridioides difficile infection highlight the need for novel agents with unique mechanisms of action for treating the infection.
Updates include novel and revised breakpoints for azithromycin, polymyxins, daptomycin, and cefiderocol.
In the August Editor-in-Chief's Letter, Dr. Jason Gallagher discusses how we can improve outpatient antimicrobial stewardship.
The story of penicillin and cefazolin.
Optimal dosing of daptomycin is unknown, but study results suggest higher doses are required for successful clinical and microbiological outcomes.
Optimizing the relationship between infection prevention and antimicrobial stewardship.
Numerous studies need to be performed to ensure adequate antimicrobial dosing, partic­ularly in the setting of renal impairment and critical illness.
Fosfomycin is an attractive potential option because it does not cross-react with other antimicrobials, making it a good choice in patients with extensive drug allergies.
Relevant existing reports, though limited, demonstrated positive outcomes and suggest a promising space for pharmacy practice growth in outpatient antimicrobial stewardship.
This In the Literature piece considers a fixed-dose strategy for administering daptomycin in obese patients.
This In the Literature piece explores if we can mitigate some of the adverse reactions that are being seen in obese patients who receive vancomycin through AUC-dosing.
Warnings and concerns regarding fluoroquinolones are on the rise, but the antibiotics still play a role, albeit more limited, in the treatment of various infectious diseases.
A commentary on β-lactam combination therapy for methicillin-resistant Staphylococcus aureus bacteremia.
What can clinicians do now that increasing resistance has limited oral treatment options for outpatient cystitis?
Are there advantageous effects to use of adjunctive IVIG in the treatment of STSS with clindamycin?
The globalization of antibiotic stewardship programs is necessary in the fight against antibiotic resis­tance.
Hospital-acquired and ventilator-associated pneumonia account for 22% of all hospital-acquired infections.
Revised DHHS and IAS–USA guidelines provide new insight for physicians managing patients with HIV.
The drug presents a new option for patients at high risk of infections caused by organisms, such as carbapenem-resistant Enterobacteriaceae.
Despite the availability of highly active agents against HCV, HIV-infected patients require special considerations for drug interactions when considering treatment options.