Antibiotics

Pooled analyses of 2 phase 3 trials have conclusively established the safety and effectiveness of iclaprim compared to vancomycin in the treatment of acute bacterial skin and skin structure infections (ABSSSI).

The pooled results have hammered home the promise of eravacycline for the treatment of patients with cIAIs who are colonized by drug-resistant bacteria.

An extremely virulent (hypermucoviscous) strain of Klebsiella pneumoniae that is resistant to carbapenem and colistin has been isolated for the first time from a patient in the United States.

Sixty-nine out of the 70 colistin-resistant isolates had either mcr-1 and/or mcr-3 genes.

Chelsea Drennan, PharmD(c) explains why hospital length-of-stay might be shorter in patients who are on a fluoroquinolone versus a beta-lactam.

Empiric use of fluoroquinolones looks to be an alternate option for the treatment of gram-negative bloodstream infections when risk factors for antimicrobial resistance are not present.

A lack of coordination among regulating bodies, pharma manufacturers, standard development organizations, and laboratory testing device companies has muddied efforts to stop antibiotic resistance; the 21st Century Cures Act aims to fix that.

Increased stewardship may reduce administration of drugs to low birth-weight babies designed to prevent early-onset sepsis.

Stay up-to-date on the latest infectious disease news by checking out our top 5 articles of the week.

Bruce A. Mueller, PharmD, explains the risk factors for augmented renal clearance.

Nabriva Therapeutics plans to file a New Drug Application with the FDA in the fourth quarter of 2018.

Bruce A. Mueller, PharmD, shares some of the pharmacokinetic alterations that occur in patients who are in acute kidney failure in the intensive care unit.

Comparing 2 commonly prescribed treatments for urinary tract infections, an international team of researchers discovers that 1 is clearly superior.

Kenneth P. Klinker, PharmD, and Jason M. Pogue, PharmD, share some strategies to address beta-lactam dosing issues that they employ at their institutions.

Edward J. Septimus, MD, explains how smaller hospitals can overcome the challenges that come with having fewer resources to implement a robust antibiotic stewardship program.

The drug met its primary endpoint of noninferiority to vancomycin at both 48 to 72 hours after drug initiation and test of cure.

Jason M. Pogue, PharmD, discusses the challenges clinicians face when dosing beta-lactams based on the current guidelines.

In case you missed them, we’ve compiled a list of the latest recalls posted this week.

Bruce A. Mueller, PharmD, shares how clinicians in the inpatient setting can quantify acute kidney injury in adults on antibiotics.

A new study shows the benefits of widespread antibiotic distribution, but what about concerns about encouraging antibiotic resistance?

A study shows that pharmacist-driven education and encouragement of antibiotic self-stewardship can decrease the duration of therapy for broad-spectrum antibiotics.

A new literature review offers a summary of the latest research into uncomplicated bacteremia.