Antibiotics

The Cystic Fibrosis Foundation has awarded Motif Bio with $120,000 that will fund in vitro testing for the development of iclaprim to benefit patients with cystic fibrosis who have lung infections.

The FDA has approved Allergan's sNDA to expand the approved use of AVYCAZ (ceftazidime and avibactam), to include the treatment of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP) caused by certain susceptible Gram-negative microorganisms.

The World Health Organization (WHO) released its first report on antibiotic resistance surveillance data.

Historically, postoperative pulmonary complications have been the most common serious adverse event following upper abdominal surgery, with incidence rates ranging from 10% to 50%.

Dr. Richard Vickers, explains how ridinilazole affected the gut microbiome in participants of a phase 2 study.

More than $2 billion was invested in research and development relevant to the issue of antimicrobial resistance in 2016 alone.

Glenn Tillotson, PhD, FIDSA, discusses the costs of drug development.

A new article suggests that in order to combat antibiotic resistance in lower- and middle-income countries, particular attention needs to be paid to emerging One Health challenges.

A new study confirms the ribavirin steady-state serum levels that correspond to high rates of efficacy and low adverse events.

Dr. Richard Vickers, discusses how ridinilazole showed superior efficacy for the treatment of C. diff when compared with vancomycin in a phase 2 study.

A recent study compares the effectiveness of a novel fidaxomicin therapy with vancomycin for the treatment of C. difficile.

Dr. Richard Vickers, explains how ridinilazole is unique in its spectrum of activity compared with other antibiotics that target C. diff and have been approved or are in development.

Rates of re-hospitalization and long-term health effects remain high among sepsis survivors, which is why researchers are outlining ways to help sepsis patients after hospital discharge.

The CDC releases first comprehensive reports on state progress made in the fight against antibiotic resistance since Congress’ investment in CDC’s Antibiotic Resistance Solutions Initiative.

A recent study suggests that the new antibiotic combination ceftazidime-avibactam may be a useful alternative for treating hospital-acquired pneumonia.

Leonard Sigal, MD, explains the potential adverse consequences of long-term antibiotic therapy.

Patients in intensive care units are at greater risk of acquiring antimicrobial-resistant infections, and now, a group of international infectious disease experts ar calling for better protection for these high-risk patients.

Intra-abdominal infections (IAIs) are defined as disease processes occurring in normally-sterile parts of the abdominal cavity, and are generally treated mechanically, such as by surgery.

Leonard Sigal, MD, explains why Lyme disease is sometimes overdiagnosed or overtreated.

A recent webinar hosted by the Centers for Disease Control and Prevention and nursing organizations highlighted the important role of nurses in implementing hospital antibiotic stewardship programs.

In a recent Association of Health Care Journalists webcast, 2 experts discussed the growing challenge of antibiotic resistance, and highlighted current and emerging strategies to reduce this major public health threat.

The Infectious Diseases Society of America’s (IDSA) decision not to endorse the 2016 Surviving Sepsis Campaign Guidelines comes from disagreement on the diagnosis and management of the microbial etiology of the disease.

Daniel Diekema, MD, describes recent developments made in rapid and molecular diagnostic testing in the microbiology lab, and how these tests strengthen infection prevention efforts.

By making this information available the FDA hopes to help improve patient outcomes, better manage antibiotic use, and decrease antimicrobial resistance.

Could forcing pathogens to compete for resources be the key to fighting drug-resistance and extending the lives of existing drugs?

This approach could significantly cut down on the cost and time needed to develop new antibiotics, which is critical considering the current antibiotic landscape.

Researchers on a new study have added more unwanted effects to the list of side effects from these life-saving drugs, further supporting the call for appropriate antibiotic use.

A blood oxygen level test in addition to 3 other noninvasive tests may be key to helping general practitioners diagnose pneumonia and avoiding unnecessary antibiotic prescriptions.

A new study finds that many patients who are hospitalized for candiduria are not treated in compliance with IDSA guidelines.

A recent study finds that prolonged infusion of antipseudomonal β-lactams in patients with sepsis was associated with significantly less mortality when compared with short-term infusion.